As a member of the original family of extracellular nucleotide-sensitive receptors34, UDP-glucose-specific G(i) protein-coupled P2Y receptor (P2RY14) has been extensively demonstrated to play a role in the development and progression of various malignancies, including glioma cells35, lung adenocarcinoma36, acute lymphoblastic leukemia37. Here, P2RY14 is linked to central nervous system cancer.