Besides, Lingguizhugan Decoction (113) improved insulin resistance in overweight/obese patients with MASLD by increasing the levels of DNA N6-methyladenine modification of protein phosphatase 1 regulatory subunit 3A (PPP1R3A) and autophagy related 3 (ATG3). Here, PPP1R3A is linked to metabolic dysfunction-associated steatotic liver disease.