An increased number of mast cells have been demonstrated in angiogenesis associated with vascular tumors, like hemangioma and hemangioblastoma, as well as several hematological and solid tumors, including lymphomas, multiple myeloma myelodysplastic syndrome, B-cell chronic lymphocytic leukemia, breast cancer, gastric and colon-rectal cancer, uterine cervix cancer, melanoma, and pulmonary adenocarcinoma, in which mast cell accumulation correlate with increased neovascularization, mast cell VEGF and FGF-2 expression, tumor aggressiveness and poor prognosis (40). The gene discussed is VEGFA; the disease is melanoma.