TNF and inflammatory response: Chen Z et al. created an inflammatory degeneration model by treating chondrocytes with TNF-α and found that the overexpression of miR-30b downregulates autophagy genes and upregulates the expression of pro-apoptotic genes, while inhibition of miR-30b enhances autophagy and alleviates chondrocyte degradation, which plays a protective role in inflammation-induced osteoarthritis (31).