Various growth factors closely implicating in myofibroblast activation, endothelial to mesenchymal transformation (EndoMT) or epithelial to mesenchymal transformation (EMT), which are crucial for ILD SSc genesis, like platelets derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ), have been found on the EVs surface or as their internal storage pool.[2,12]. The gene discussed is VEGFA; the disease is systemic sclerosis.