NOD2 and Bloom syndrome: BS with vasculitis is rare, with the middle part of the aorta, renal artery, and cerebral artery most commonly involved and typically asymptomatic.[2] Zeng reported a 20-year-old girl initially misdiagnosed with adolescent idiopathic arthritis who developed renal arteritis at 17 and was later diagnosed with BS due to a heterozygous NOD2 mutation.[3] Cardiovascular lesions in BS patients are often identified when hypertension develops during follow-up, caused by large-artery vasculitis.[4] The two cases we report presented with unusual BS presentations mimicking Takayasu’s arteritis.