The etiology of anti-MDA5-positive DM remains elusive, despite epidemiological studies have pointed to a possible viral etiology, supporting the known activity of MDA5 as a viral RNA sensor.[2] Interestingly, during the corona virus disease 2019 (COVID-19) pandemic, case reports and case series have described an emergence of anti-MDA5 antibody-positive myositis and ILD.[3]. The gene discussed is IFIH1; the disease is myositis disease.