Glioblastoma exhibits one or more of the following histological and genetic hallmarks: microvascular proliferation, necrosis, mutation of the telomerase reverse transcriptase (TERT) promoter, amplification of the epidermal growth factor receptor (EGFR) gene, and chromosomal alterations such as +7/−10 copy number changes. This evidence concerns the gene EGFR and glioblastoma.