CDH1 and colorectal carcinoma: MCC interactions with E-cadherin and β-catenin in the HCT116 cell line were proven via co-immunoprecipitation studies, and MCC ablation promoted HCT116 invasiveness, indicating that MCC serves as a tumor suppressor in the context of the regulation of E-cadherin-mediated cell–cell adhesion of CRC cells (50).