In the multivariate Cox regression analysis, after adjusting for age, sex immunotyping, and the presence of chromosomal abnormalities and fusion genes, the presence of asparaginase re-exposure was an independent risk factor for EFS in children with intermediate-high risk ALL (p=0.010; HR: 5.957; 95% CI: 1.519–23.361) (Figure 2). This evidence concerns the gene ASPG and acute lymphoblastic leukemia.