(18) in addition to their findings on cell viability, discovered that blue laser at 4-8 J/cm2 reduced bladder cancer cell migration, invasion, and epithelial-mesenchymal transition (EMT) by downregulating MMP-2/9, Snail, N-cadherin and phospho-MEK/ERK while increasing E-cadherin, suggesting inhibition of cancer progression via suppression of the MAPK/MEK/ERK pathway. This evidence concerns the gene MMP2 and urinary bladder carcinoma.