RIGI and bronchiolitis: While some studies have previously demonstrated that SCFA-acetate provides defense against RSV through a GPR43- and interferon-α/β receptor (IFNAR)-dependent mechanism (Antunes et al., 2019), Antunes et al. (2022) found that SCFAs had protective effects against various RSV viral strains and on samples collected from children diagnosed with bronchiolitis, and reported the role of retinoic acid-inducible gene I (RIG-I) in modulating the antiviral response induced by SCFA-acetate.