This study integrates various osteoporosis-related omics datasets, juxtaposes differentially expressed genes/proteins across diverse cell types with genes exhibiting bone metabolism-related phenotypes in the IMPC database, and identified 9 genes including PPP2R2A, RRBP1, HSPB6, SLC22A15, ADAMTS4, ATP8B1, CTNNB1, ROBO1, and EFR3B, which may contribute to pathogenesis of osteoporosis. The gene discussed is EFR3B; the disease is osteoporosis.