It may also be speculated that H3.3G34R and IDH1/2 mutations co-operate with ATRX-mutated glioblastomas, leading to alternative lengthening of the telomeres, which is a process that is sometimes regulated through the HR pathways in the absence of or compromised functions of telomerase genes (Udugama et al., 2021). This evidence concerns the gene IDH1 and glioblastoma.