Adult secondary glioblastoma multiforme (GBM) harbours isocitrate dehydrogenase 1/2 (IDH1/2) mutations (about 98%), which are rarely found in childhood GBM, and also regulate methylation at the H3K27 and H3K36 residues (Sturm et al., 2012). This evidence concerns the gene IDH1 and glioblastoma.