MYCN and central nervous system neoplasm: Adult CNS tumours have high CDK6 amplification, 10q loss, and 17q gain, whereas paediatric cases have a high frequency and high specificity of 3q and 4q losses across MYC/MYCN oncogene amplification, suggesting variations in the chromosomal abnormalities between adult and paediatric CNS tumours (Korshunov et al., 2016; Liu et al., 2023; Korshunov et al., 2010).