Through bidirectional investigation approach, it could be inferred that certain biomarkers are more likely to be found later in the course of the illness, like bNGF, FGFBasic, GCSF, GROa, IL-13, IL-5, IL-7, MCSF, SCGFb in gastric polyps, and CTACK, MIF in colonic polyps. Here, CSF1 is linked to polyp of colon.