The three highest-ranked causal circulatory cytokines for colonic polyp were: MIP1b (MIP = 0.752, MACE = −0.033), IL-6 (MIP = 0.196, MACE = −0.012), IL-18 (MIP = 0.112, MACE = 0.004). The gene discussed is IL6; the disease is polyp of colon.