Through lasso Cox regression analysis, we constructed a signature consisting of ten genes (ATP6V0D1, CD74, GSTP1, MLKL, NFATC4, TRAF1, TRIM27, VPS13C, XBP1, and ZBP1), with five from apoptosis, three from autophagy, and two genes from necroptosis (Figure 3A), which not only play a crucial role in the pathogenesis and the development of melanoma but also serve as a potential factor in reshaping the immune microenvironment, mediating metastasis, and influencing drug resistance. The gene discussed is MLKL; the disease is melanoma.