Collectively, these processes are known as sprouting and splitting.14 Several angiogenic GFs and their receptors have been discovered so far, with the most notable ones being angiopoietins (ANG), PDGF/R, basic fibroblast growth factor (bFGF/R, FGF/R-2), VEGF/R, TGF/R, insulin-like growth factor/receptor, and EGF/R.15,16 Antiangiogenic drugs for cancer treatment primarily target the inhibition of these factor's receptors.17Fig. 1 illustrates the chronological sequence of identifying antiangiogenic factors that are crucial targets for fighting against various forms of carcinoma. Here, VEGFA is linked to cancer.