VEGF-activated VEGFR-2 triggers the phosphorylation of multiple proteins in the signalling pathways, such as Akt (protein kinase B), mTOR (mammalian target of rapamycin), Erk1/2 (extracellular signal-regulated kinase 1/2), FAK (focal adhesion kinase), and p70S6K (ribosomal protein S6 kinase), thereby facilitating tumour angiogenesis.64 These proteins are prime targets of VEGFR inhibitors.65 This evidence concerns the gene VEGFA and neoplasm.