VEGFA and neoplasm: VEGFR-2 is more active as a tyrosine kinase than VEGFR-1 but has a lower affinity for VEGF-A.69 Tumour cells release VEGF, which activates its receptor VEGFR-2, promoting vascular development and supplying oxygen and nourishment into hypoxic parts of tumour tissues.70 Multiple inquiries have demonstrated that the VEGF/VEGFR-2 signalling pathway exerts direct control over neuronal development and its function, particularly by promoting increased branching of axons.71,72