KDR and neoplasm: The main places where phosphorylation happens are Y951, Y1054, Y1059, Y1175, and Y1214.53 Following VEGF binding, the primary auto-phosphorylation sites in human VEGFR-2, Y1175 and Y1214, activate various downstream pathways, including PI3K, p38MAPK, FAK, Src, and Akt, which are usually hyperactivated in several tumours.54 The analysis of the binding site reveals that the VEGFR-2 active site consists of four main components: the hinge area, two hydrophobic areas (hydrophobic-I and hydrophobic-II), and the hydrogen bond-rich region.55,56