For instance, ST has delineated five distinct immune microenvironmental subtypes in hepatocellular carcinoma, uncovering the heterogeneity of tumor-associated neutrophils (TAN) and identifying key subpopulations, such as CCL4+ and PD-L1+ TAN, which are implicated in tumor promotion, thus suggesting novel therapeutic targets for liver cancer (12). This evidence concerns the gene CD274 and neoplasm.