In a cohort of 152 HER2+ ductal breast carcinomas, cellular constituents of the TME displayed well-defined three-dimensional localization patterns; for instance, T lymphocytes exhibit a propensity to aggregate perivascularly and along vascular networks, whereas macrophage accumulations manifest distinct distributional configurations, ranging from uniform dispersion to localized aggregation (35). The gene discussed is ERBB2; the disease is breast carcinoma.