SMAD4 and colorectal carcinoma: It was observed that the protein expression of Smad4 in NKp46+NK cells at 8 weeks (Wk 8) was significantly decreased compared to that at 4 weeks (Wk 4) (Figures 2F-H).When analyzed collectively, we observed a widespread decrease in Smad4 expression in mouse NK cells within CRC tumor TME.