In type 2-high asthma, activated eosinophils release cytotoxic granular proteins, including eosinophil cationic protein (ECP), major binding protein (MBP), eosinophil peroxidase (EPO), and eosinophil-derived neurotoxin (EDN), LTC4, and platelet-activating factor (PAF), leading to airway constriction, mucus secretion, and increased blood permeability (161). The gene discussed is RNASE2; the disease is asthma.