Large-scale GWAS have confirmed that SNPs in IL33 (located at 9p24.1), IL1RL1 (encoding the IL-33 receptor; also called suppression of tumorigenicity 2 [ST2], located at the 2q12.1 locus), and TSLP (5q22.1 locus) are positively associated with the risk of developing asthma; furthermore, epigenome analysis has revealed that they frequently exhibit an active chromatin state (72). This evidence concerns the gene IL1RL1 and asthma.