Interestingly, while high CNI trough levels and the use of MMF seem to not favor the development of antiviral humoral and cellular responses after infection or vaccination (37, 38), the use of mTOR inhibitor (mTOR-i) has been shown to boost antiviral cellular immune responses after viral infection or vaccination in different settings (13, 39, 40). The gene discussed is MTOR; the disease is viral infectious disease.