A complete hemogram combined with Hb HPLC is a reliable, robust, and rapid technique for screening thalassemias and hemoglobinopathies.7,8 India has reported a few extensive studies on Hb HPLC analysis to identify hemoglobinopathies in hospitals and community-based screening programs from various parts of the country9,10 and southern India.11-13 However, there is a paucity of data from this region, especially the Puducherry UT. This evidence concerns the gene GSTM1 and thalassemia.