In this regard, screening with hemoglobin high-performance liquid chromatography (Hb HPLC) is an effective tool for detecting hemoglobin variants.7 This study aimed to screen for thalassemia and hemoglobinopathies in a referral hospital-based population in southern India and map the prevalence with the regions from which these patients were referred. Here, GSTM1 is linked to hemoglobinopathy.