PCSK9 and familial hypercholesterolemia: CI: confidence interval; ASCVD: atherosclerotic cardiovascular disease; HeFH: heterozygous familial hypercholesterolemia; HoFH: homozygous familial hypercholesterolemia; LDL-C: low-density lipoprotein cholesterol; PCSK 9: proprotein convertase subtilisin/kexin type 9