The relevance was further emphasised in a recent study [14] where four out of five patients diagnosed with CRC and FIT results <10 μg Hb/g presented with anaemia, either with or without iron deficiency. Consistently, a study in Dundee, Scotland, United Kingdom, corroborated similar findings with all patients found to have missed CRC with negative FIT (<10 μg Hb/g) found to have iron deficiency anaemia (IDA) [15]. The gene discussed is GSTM1; the disease is anemia.