White adipose tissue of surrounding breast tissue, which produces a variety of factors that directly regulate the breast cancer tumor microenvironment, also contribute to pro-angiogenic signaling by releasing VEGF, basic fibroblast growth factor (bFGF), matrix metalloproteases (MMPs), and interleukin 8 (IL-8) (41, 42). Here, FGF2 is linked to breast carcinoma.