Three distinct variants of the MEN2 spectrum, categorized as MEN2A, MEN2B (alternatively designated as MEN3), and Familial Medullary Thyroid Carcinoma (FMTC), are recognized based on the presence or absence of associated conditions like hyperparathyroidism and pheochromocytoma, along with distinctive clinical manifestations (3). The gene discussed is RET; the disease is familial medullary thyroid carcinoma.