TNF and colitis: Researchers have developed various methods to deliver anti‐TNF‐α with bacteria, such as bacteria autonomously secreting anti‐TNF nanobody[53] or scFv,[54a] or displaying TNF‐α‐binding affibody on the surface.[54, 69] These methods reduced inflammation in colitis mice, but the therapeutic effect of TNF‐α‐binding L. lactis did not differ significantly from control L. lactis.