CSF2 and neoplasm: Hence, we constructed a novel HA@RTD hydrogel with advantages in three aspects: (1) Irradiated tumor cell debris not only contains a broad spectrum of tumor antigens but also personalized antigens for the tumor, which can promote the TCR diversity and enhance the anti‐tumor effect for the heterogeneous tumor cells; (2) Overexpressing GM‐CSF on the membrane helps activate the DCs and have the adjuvant effect without the toxicity.