IFNG and diabetes mellitus: found in a DM mouse model induced by streptozotocin that Th1 cells were significantly suppressed in DM mice, and the synthesis of IL‐12 was also reduced when they were co‐infected with MTB.[101] However, Th1 cells primarily produce IFN‐γ, and IL‐12 can promote the production of IFN‐γ by innate immune cells, which is a major effector cytokine for resistance against MTB.