CD4+ T cells play a critical role in anti‐tuberculosis immunity, and their secretion of interferon‐gamma (IFN‐γ) promotes the proliferation of T lymphocytes and activation of macrophages.[19, 20, 21, 22] However, under the influence of high blood glucose, the activation of CD4+ T cells may be delayed, resulting in a reduced secretion of IFN‐γ.[23, 24]. Here, CD4 is linked to tuberculosis.