CD8A and diabetes mellitus: found that in DM‐TB patients, the levels of pro‐inflammatory cytokines secreted by CD8+ T cells, including IFN‐γ, IL‐17, and IL‐2, were elevated, while the expression of cytotoxic markers perforin, granzyme B, and CD107a on CD8+ T cells was significantly reduced.[78] With the increase in the secretion of pro‐inflammatory cytokines and the decrease in the ability to clear bacteria by CD8+ T cells, the body's resistance is lowered, leading to exacerbation of tissue pathological damage.