engineered a tumor microenvironment‐responsive CS‐NG nanocarrier system, which is sensitive to hyaluronidase (HAase, an overexpressed enzyme at the tumor microenvironment) and can enzymatically assemble into microsized extracellular depots for extracellular drug delivery and sustain release (Figure 3B).[74] This innovative system exhibits a unique “morphing aggregation” behavior specifically at tumor sites by transglutaminase (TG) catalyzes the crosslinking of glutamine (Gln) and lysine (Lys) on human serum albumin (HAS) surface of CS‐NG nanocarrier to form depots. Here, ALB is linked to neoplasm.