Furthermore, among PSA > 10 group PCa patients with the SNP rs11977021, having the CT+TT heterozygote increased the risk of perineural invasion (OR 1.777; 95% CI, 1.038-3.041; p<0.05), lymphovascular invasion (OR 1.824; 95% CI, 1.024-3.249; p<0.05), and biochemical recurrence (OR 1.601; 95% CI, 1.007-2.545; p<0.05) compared with having the CC wild-type (Table 5). Here, KLK3 is linked to posterior cortical atrophy.