CHEK1 and familial pancreatic carcinoma: The laboratory results found that in pancreatic cancer cells, Metachromin C can inhibit cell growth, arrest the cell cycle in the S phase, and induce DNA damage to initiate DNA repair pathways, activating a series of DNA repair-related proteins (including ATM, ATR, P53, BRCA1, ChK1 and ChK2), which means that cancer cells try to repair damaged DNA, but it may not be enough to repair completely, and the damage cannot be recovered, which may cause cell death.