In males with CAH, whole-body BMD Z-score and total BMD in g/cm2 were directly associated with 17OHP concentration [r = 0.74 (p = 0.006) and r = 0.59 (p = 0.026), respectively]; total BMD in g/cm2 was also significantly related to DHEAS levels (r = 0.695, p = 0.012), and the lumbar BMD Z-score was inversely related to SHBG levels (r = −0.669, p = 0.017). This evidence concerns the gene SHBG and congenital adrenal hyperplasia.