We also observed that knockdown ofLINC00365 significantly slowed the growth of subcutaneously transplanted tumors in nude mice; reduced the size of transplanted tumors compared with those in the control group; decreased the expression of miR-221-5p; increased the mRNA expression levels of caspase-1, caspase-11, NLRP3 and GSDMD; and increased the number of pyroptosis bodies in transplanted tumor tissues. This evidence concerns the gene CASP1 and neoplasm.