SQSTM1 and hepatocellular carcinoma: In these settings, in response to hepatoma‐derived factors, macrophages use the toll‐like receptor 2 (TLR2) pathway to get the NF‐κB/RELA cytosolic ubiquitination, which is then degraded through a SQSTM1/p62‐dependent mechanism, thus favoring an M2‐like polarization (Fig. 4C).