INS and diabetes mellitus: The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI‐2D) sub‐study of 1075 participants without DPN showed that the 4‐year cumulative incidence of DPN was significantly lower in the insulin‐sensitizing (metformin and TZD) compared with the insulin‐providing (insulin and SU) strategy, even after adjustment for in‐trial HbA1c.5