CD8A and neoplasm: A well-characterized example of “altered self” antigens is represented by T-cell epitopes associated with altered peptide processing (TEIPP), a class of non-mutational tumor antigens that arise specifically in transporter associated with antigen processing- (TAP) deficient tumors and efficiently induce a functional antitumor CD8+ T cell response in these tumors, but not against TAP-expressing counterparts on healthy tissues [52–55].