While these results are at odd with the bulk of the evidence supporting an immuno-suppressive role for lactate in tumors (see later), they provide an interesting system to study the possible antagonism between D-2HG and lactate on the survival and the function of tumor-infiltrating CD8 + T cells, in which threshold-controlled effects of the two oncometabolites can tip the balance towards an immune-suppressive vs. an immune-promoting phenotype. Here, CD8A is linked to neoplasm.