Hypertension may contribute to cancer development through several mechanisms, including remodeling of the extracellular matrix25,65, influencing the secretion of VEGF (Vascular Endothelial Growth Factor)25,66, generating ROS (Reactive Oxygen Species)25, and affecting the functioning of the RAA (Renin–Angiotensin–Aldosterone System)67,68 and MMPs (matrix metalloproteinases)69. This evidence concerns the gene REN and cancer.