Recent in vitro investigation demonstrated that nanocombinations of the purified bovine LPO and lactoferrin (LF)-coated Cu and Fe nanometals provoked their apoptotic effect via cell cycle arrest mechanism with up-regulating proapoptotic genes (p53) and downregulating oncogenes (Bcl-2) in the treated MCF-7 breast cancer cells26. This evidence concerns the gene TP53 and breast cancer.