ITIH4 and infection: Early work in the SIV model demonstrated that blood myeloid CD14+ cells, which perform efferocytosis, are a reproducible correlate of decreased risk of infection in animals vaccinated with ΔV1 envelope immunogens delivered by the DNA/ALVAC/gp120-alum platform20,21, and systemic vaccination induces epigenetic change in monocytes that acquire an increased ability to clear apoptotic cells20.