HE, IHC staining and WB showed the expression of MAT1A, CCND1, proliferation marker Ki67 and glycolytic marker (ALDOC, HK2) in tumor tissues, emphasizing the regulation of MAT1A and CCND1 on NSCLC cells (Fig. 6C, D). The gene discussed is MKI67; the disease is non-small cell lung carcinoma.