Additionally, enhanced JAK-STAT signaling has been identified as a factor responsible for the severe GVHD phenotype induced by MicroRNA-146a deficient dendritic cells.25 Early inhibition of JAK1/JAK2 in clinic setting has emerged as a potential therapeutic strategy, which may minimize GVHD evolution and decrease second line therapies. The gene discussed is JAK1; the disease is graft versus host disease.