A study tested the relationship between the two and concluded that oxidative stress associated with hyperglycemia caused an increase in activity and expression of PKC, which increased GRK2 translocation to the proximal tubular membrane, subsequent phosphorylation of the D1‐like receptors and their uncoupling from G proteins and loss of responsiveness to agonist stimulation.51 This evidence concerns the gene GRK2 and Hyperglycemia.