Although less is known about the role of FAM83F in oncogenesis compared with other family members, it is linked to oesophageal small-cell carcinoma [7], papillary thyroid cancer [8], non-small cell lung cancer [9–11] and breast and cervical cancer [12,13]; increased expression is also implicated in poor patient survival in other cancers [14]. The gene discussed is SACK1F; the disease is cancer.