CS-exposed Clec2pltKO mice had increased autoantibodies to a wide variety of antigens, including autoantibodies that are typically seen in autoimmune diseases, such as Sm, SSA-A, Jo-1, Scl-70, and autoantibodies to complement proteins (Supplemental Fig. S3, A–F) (44, 47, 48). This evidence concerns the gene VTN and autoimmune disease.