Collectively, the micro-CT findings from our study, which highlight predominant UIP features, combined with our previous observations of IPF-signature lesions in histology and shared molecular signatures with IPF patients, support the relevance of conditional Nedd4-2−/− mice as a model of IPF, and potentially other ILD and ILA. Here, TNFRSF9 is linked to idiopathic pulmonary fibrosis.