Post mortem micro-CT imaging of these moribund mice showed that IPF-like lung disease was substantially more severe in this group of mice with end-stage lung disease compared with conditional Nedd4-2−/− littermates from the longitudinal study cohort that survived and were studied 5 mo after doxycycline induction (Fig. 5). Here, NEDD4L is linked to idiopathic pulmonary fibrosis.