NEDD4L and fibrosis: Specifically, reticulations and consolidations affected almost the entire lung (Fig. 5B), and the post mortem micro-CT fibrosis score and all of its subscores were markedly increased in these moribund mice compared with conditional Nedd4-2−/− mice in the longitudinal study group that were studied after 5 mo of induction (Fig. 5, C–I).