To study the onset and progression of IPF-like lung disease in conditional Nedd4-2−/− mice at higher resolution, we performed in vivo and post mortem micro-CT imaging of conditional Nedd4-2−/− mice at the same time points as for the longitudinal in vivo studies in a cross-sectional study design (n = 5–12 mice/time point) (Fig. 2A). The gene discussed is NEDD4L; the disease is idiopathic pulmonary fibrosis.