IKZF1 and precursor B-cell acute lymphoblastic leukemia: 20% of genes aberrantly upregulated in IKZF1 DN B-ALL were IKZF1 fast-repressed genes, and often associated with early-repressed pre-B SEs (Itga5, Endod1, Ramp1, Serpinf1, Gins2, Hs3st2 and Hs3st3b1, Fig. 4CD).