GFRA2 and precursor B-cell acute lymphoblastic leukemia: Finally, we find substantial overlap between early repressed genes identified here and aberrantly upregulated genes in IKZF1-mutated B-ALL, and several IKZF1-repressed super enhancer associated genes ITGA5, CCND2, GFRA2, BCL11A have been implicated in multiple cancers76–80.