IKZF1 and precursor B-cell acute lymphoblastic leukemia: To assess the relevance of IKZF1-regulated genes identified in B3 cells to B-ALL, we compared fast-repressed genes identified here with genes deregulated in IKZF1 DN-mutant B-ALL, where expression of DN IKZF1 results in increased expression of adhesion/integrin and cell cycle genes33.