Furthermore, in MIA PaCa-2/R tumor tissues, the co-administration of SIAIS562055 with MRTX849 resulted in significant degradation of SOS1, leading to a more pronounced reduction of ERK phosphorylation and enhanced cleavage of caspase-3 (Fig. 4G; Supplementary Fig. S7B and S7C). The gene discussed is SOS1; the disease is neoplasm.