Our results are generally consistent with previous studies, where compound heterozygotes for the splice site variant with nontruncating variants had less severe HL: c.[-23+1G>A];[269T>C] (moderate HL), c.[-23+1G>A];[551G>C] (moderate HL), c.[-23+1G>A];[-254C>T(;)516G>C] (moderate HL), compared to the GJB2 genotypes where splice site variants in a compound-heterozygous state with truncating variants had a more severe degree of HL: c.[-23+1G>A];[35delG] (profound HL), c.[-23+1G>A];[327_328delGGinsA] (profound HL) [18, 19, 77]. The gene discussed is GJB2; the disease is Hodgkins lymphoma.