Moreover, a large systematic analysis of 270 unrelated patients with biallelic GJB2 pathogenic variants (30 Belgian, 131 Italian, 42 Spanish, and 74 American patients) [18] and a multicenter study of 1,531 patients with biallelic GJB2 pathogenic variants (90% of participants were of Caucasian origin) [19] as well as a meta-analysis of more than 200 original articles [8] on the genotype–phenotype features of hearing function in patients with DFNB1A showed extremely variable hearing phenotypes that ranged from mild to profound HL [8, 18, 19]. This evidence concerns the gene GJB2 and Hodgkins lymphoma.