In this study, the expression of U17 snoRNA decreased in the liver of Snhg3-HKO mice and unchanged in the liver of Snhg3-HKI mice, but overexpression of U17 snoRNA had no effect on the expression of SND1 and PPARγ (Figure 7—figure supplement 1A–C), indicating that Sngh3 induced hepatic steatosis was independent on U17 snoRNA. Here, PPARG is linked to fatty liver disease.