Given Snhg3 was associated with hepatic nutrition change, the role of Snhg3 was further confirmed by constructing hepatocyte-specific Snhg3 knock-out (Snhg3-HKO) mice that were then induced obesity with a high-fat diet (Figure 2A and Figure 2—figure supplement 1A, B). This evidence concerns the gene SNHG3 and obesity disorder.